Substantial Underestimation Of Sars Cov 2 Infection In The Nature

Sep 9, 2020 Art Reingold, Benjamin F. Arnold, Alan Hubbard & Jade Benjamin-Chung. Nature Communications 11, Article number: 4507 ( 2020 ) Cite this article. 75k Accesses. 232 Citations. 1262 Altmetric....

When correcting for incomplete testing and imperfect test accu-racy, we estimated that the total number of SARS-CoV-2 infec-tions in the U.S. by April 18, 2020 was 6,454,951 (19 per 1000) an ...

Sep 9, 2020 PMC7481226. Accurate estimates of the burden of SARS-CoV-2 infection are critical to informing pandemic response. Confirmed COVID-19 case counts in the U.S. do not capture the total burden of the pandemic because testing has been primarily restricted to individuals with moderate to severe symptoms due to limited test availability.

Sep 9, 2020 The 95% simulation interval for the number of estimated infections in the U.S. was 2,240,74014,856,756 (Supplementary Fig. 1 ). This corresponds to an estimated number of SARS-CoV-2 infections 3 to 20 times higher than the number of confirmed cases. Nationally, we estimate that 84% (simulation interval: 6499%) of the difference between ...

May 18, 2020 Substantial underestimation of SARS-CoV-2 infection in the United States. Sean L. Wu, Andrew N. Mertens, +10 authors. J. Benjamin-Chung. Published in Nature Communications 18 May 2020. Medicine, Environmental Science. TLDR.

Alan Hubbard, Jade Benjamin-Chung. Affiliations. DOI. https://doi.org/10.1038/s41467-020-18272-4. Journal volume & issue. Vol. 11, no. 1. pp. 1 10. Abstract. Read online. Estimating the extent of SARS-CoV-2 infection in a population is challenging due to the limitations of testing.

Mar 20, 2024 Despite huge efforts in diagnostic testing of individuals, the underestimation of the actual number of SARS-CoV-2 infections remains significant due to the large number of undocumented cases.

Abstract. Accurate estimates of the burden of SARS-CoV-2 infection are critical to informing pandemic response. Confirmed COVID-19 case counts in the U.S. do not capture the total burden of the pandemic because testing has been primarily restricted to individuals with moderate to severe symptoms due to limited test availability.

Substantial underestimation of SARS-CoV-2 infection in the United States SL Wu, AN Mertens, YS Crider, A Nguyen, NN Pokpongkiat, S Djajadi, ... Nature communications 11 (1), 4507 , 2020

May 13, 2021 The contagiousness, dynamics of the pathogen, and mobility of the general population incurred the occurrence of underestimation of infection (i.e., the unidentified cases and the gap with the identified cases) that was potentially substantial in magnitude, which was supposed to connect with subsequent cyclical outbreaks in practice.

Sep 22, 2020 Substantial underestimation of SARS-CoV-2 infection in the United States. Wu et al. Nature Communications (September 9, 2020). Key findings: By April 18, 2020, the estimated cumulative SARS-CoV-2 incidence in the US was ~2%.

Aug 8, 2021 By analyzing over 350 studies, we estimate that the percentage of infections that never developed clinical symptoms, and thus were truly asymptomatic, was 35.1% (95% CI: 30.7 to 39.9%).

Sep 9, 2020 The authors estimate that there were 6,454,951 cases of SARS-CoV-2 infection (19 per 1,000 people). This estimate is about 9 times larger than the number of confirmed cases during the same period (2 per 1,000 people) and suggests that 89% of infections were undocumented.

Aug 14, 2023 By analyzing over 350 studies, we estimate that the percentage of infections that never developed clinical symptoms, and thus were truly asymptomatic, was 35.1% (95% CI: 30.7 to 39.9%).

Sep 9, 2020 Europe PMC is an archive of life sciences journal literature.

Nov 23, 2021 1. To what extent have populations of individual countries and the global population been infected by this virus in the first year of its introduction, regardless of whether those infections have been documented? Infections include documented cases involving laboratory-confirmed diagnosis and undocumented asymptomatic or mild cases.

Dec 31, 2021 Substantial underestimation of SARS-CoV-2 infection in the United States ... High and increasing prevalence of SARS-CoV-2 infection among school-aged children during September 2021 and vaccine ...

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2 days ago In cultures of human brain cells exposed to SARS-CoV-2, substantial viral infection and replication were observed in astrocytes, with comparatively few infections observed in other cell types, suggesting that astrocytes are a major site of viral infection within the brain. 60 Older adults may be more susceptible to COVID-19, potentially due to ...

1 day ago The development of effective vaccines against SARS-CoV-2 remains a critical challenge amidst the ongoing global pandemic. This study introduces a novel approach to enhancing mRNA vaccine efficacy by leveraging the untranslated region (UTR) of TMSB10, a gene identified for its significant mRNA abundance in antigen-presenting cells. Utilizing the GEO database, we identified TMSB10 among nine ...

Oct 6, 2020 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmissible and pathogenic coronavirus that emerged in late 2019 and has caused a pandemic of acute...

Feb 21, 2023 Heterogeneous findings are assessing the potency of immune response elicited by vaccination in comparison with natural infection, with some reports of lower titers of antibodies after mRNA vaccine and others stating that vaccinations elicit stronger and broader immune responses than those after natural SARS-CoV-2 exposure (Altawalah 2021 ...

1 day ago A number of studies have suggested that influenza vaccination can provide protection against COVID-19, but the underlying mechanisms that could explain this association are still unclear. In this study, the effect of the 2021/2022 seasonal influenza vaccination on the immune response to the booster dose of anti-SARS-CoV-2 vaccination was evaluated in a cohort of healthy individuals. A total of ...

Feb 21, 2024 Prevalence of persistent SARS-CoV-2 in a large community surveillance study | Nature. Article. Open access. Published: 21 February 2024. Prevalence of persistent SARS-CoV-2...

3 days ago The risk of contracting SARS-CoV-2 via human milk-feeding is virtually non-existent. Adverse effects of COVID-19 vaccination for lactating individuals are not different from the general population, and no evidence has been found that their infants exhibit adverse effects. Yet, there remains substantial hesitation among this population globally regarding the safety of these vaccines. Herein we ...

Mar 23, 2021 Wu SL, Mertens AN, Crider YS, Nguyen A, Pokpongkiat NN, Djajadi S, et al. Substantial underestimation of SARS-CoV-2 infection in the United States. Nat Commun. 2020;11(1). [ PMC free article ] [ PubMed ]

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